Dioxanone-fused dienes enable highly endo-selective intramolecular Diels-Alder reactions.


Intramolecular Diels-Alder reactions of dioxanone-fused (Z,Z)-dienes, available in a stereoselective manner from the corresponding alcohols are described. These dienes exhibited high reactivity and high levels of endo selectivity, giving functionalized trans-fused bicyclic compounds. 
DOI: 10.1021/acs.orglett.5b01172

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