Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells.

@article{Srinivasan2009DiosgeninTA,
  title={Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells.},
  author={Sowmyalakshmi Srinivasan and Srinivas Koduru and Raj Kumar and Guhan Venguswamy and Natasha Kyprianou and Chendil Damodaran},
  journal={International journal of cancer},
  year={2009},
  volume={125 4},
  pages={961-7}
}
In recent years, Akt signaling has gained recognition for its functional role in more aggressive, therapy-resistant malignancies. As it is frequently constitutively active in cancer cells, several drugs are being investigated for their ability to inhibit Akt signaling. The purpose of this study is to determine effect of diosgenin (fenugreek), a dietary compound on Akt signaling and its downstream targets on estrogen receptor positive (ER(+)) and estrogen receptor negative (ER(-)) breast cancer… CONTINUE READING

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