Diosgenin inhibits IL-1β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes.

@article{Wang2015DiosgeninII,
  title={Diosgenin inhibits IL-1β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes.},
  author={Leisheng Wang and Tian J. Ma and Yanpin Zheng and Shiqiao Lv and Yu Li and Shaoxian Liu},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 5},
  pages={4830-6}
}
It is well known that the inflammatory cytokines play important roles in osteoarthritis (OA). Diosgenin is a steroidal saponin found in several plants including Solanum and Dioscorea species and possesses diverse biological activities including anti-inflammatory properties. However, the role of diosgenin in inflammatory responses in OA chondrocytes is still unclear. Therefore, in this study, we investigated the anti-inflammatory properties of diosgenin in human OA chondrocytes. We found that… CONTINUE READING
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