Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

  title={Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis},
  author={M. Liu and Z. Wang and Y. Ju and R. N. Wong and Q. Wu},
  journal={Cancer Chemotherapy and Pharmacology},
  • M. Liu, Z. Wang, +2 authors Q. Wu
  • Published 2004
  • Medicine, Biology
  • Cancer Chemotherapy and Pharmacology
  • PurposeDiosgenin is a steroidal sapogenin with estrogenic and antitumor properties. In order to elucidate the mechanism of its antiproliferative activity, we investigated its effects on the cell cycle and apoptosis in human chronic myelogenous leukemia K562 cells.MethodsCell viability was assessed via an MTT assay. Apoptosis was investigated in terms of nuclear morphology, DNA fragmentation, and phosphatidylserine externalization. Cell cycle analysis was performed via PI staining and flow… CONTINUE READING
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