Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

@article{Liu2004DiosgeninIC,
  title={Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis},
  author={M. Liu and Z. Wang and Y. Ju and R. N. Wong and Q. Wu},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={55},
  pages={79-90}
}
  • M. Liu, Z. Wang, +2 authors Q. Wu
  • Published 2004
  • Medicine, Biology
  • Cancer Chemotherapy and Pharmacology
  • PurposeDiosgenin is a steroidal sapogenin with estrogenic and antitumor properties. In order to elucidate the mechanism of its antiproliferative activity, we investigated its effects on the cell cycle and apoptosis in human chronic myelogenous leukemia K562 cells.MethodsCell viability was assessed via an MTT assay. Apoptosis was investigated in terms of nuclear morphology, DNA fragmentation, and phosphatidylserine externalization. Cell cycle analysis was performed via PI staining and flow… CONTINUE READING
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    References

    SHOWING 1-10 OF 37 REFERENCES
    A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells
    • 166
    • PDF
    Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis*
    • 223
    • PDF
    Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2*
    • 119
    • PDF
    Tumor Necrosis Factor-induced Apoptosis Stimulates p53 Accumulation and p21WAF1 Proteolysis in ME-180 Cells*
    • 92
    • PDF
    Regulation of the G2/M transition by p53
    • 1,435
    • PDF
    BCL-2 family members and the mitochondria in apoptosis.
    • 3,561
    • PDF
    Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis
    • 652
    • PDF