Dioscorea opposita reverses dexamethasone induced insulin resistance.

  title={Dioscorea opposita reverses dexamethasone induced insulin resistance.},
  author={Xiao-Ping Gao and Bogang Li and Hanwen Jiang and Fenglin Liu and Dayong Xu and Zhongrong Liu},
  volume={78 1},
The effects of Dioscorea opposita (huai shan yao, HSY) on dexamethasone-induced insulin resistance were investigated in vitro and in vivo. D. opposita extract reduced significantly the blood insulin and glucose levels in dexamethasone-induced diabetic rats. In vitro, HSY significantly enhanced insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Moreover, HSY increase the mRNA expression of GLUT4 glucose transporter in 3T3-L1 adipocytes. These data suggest that D. opposita has insulin… CONTINUE READING


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