Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

@article{Wang2012DioscinIC,
  title={Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.},
  author={Zhiyu Wang and Yue Cheng and Neng Min Wang and Dong Mei Wang and Ying Wei Li and Feng Han and Jian Gang Shen and De Po Yang and Xin-yuan Guan and Jian-ping Chen},
  journal={Cancer biology & therapy},
  year={2012},
  volume={13 3},
  pages={138-47}
}
Dioscin has been shown to promote anticancer activity against several forms of cancers. However, its detailed molecular mechanisms have not been clearly clarified.In this study, we demonstrate that dioscin induces apoptosis in cancer cells through the induction of oxidative stress. Treatment with cancer cells in vitro with dioscin resulted in rapid generation of reactive oxygen species (ROS) and the induction of mitochondrial pathway apoptosis in human esophageal cancer cell line Kyse510… CONTINUE READING