Diorganotin (IV) derivative of 2-thiophene acetic acid: characterizations and biological activities of {[n-Bu2SnO2C–CH2–C4H3S]2O}2

Abstract

New organotin (IV) derivatives of thiophene acetic acid have been prepared and characterized by IR, 1H- and 13C-NMR spectroscopic techniques. A single crystal of {[n-Bu2SnO2C–CH2–C4H3S]2O}2 has been synthesized and its cell parameters were measured. It crystallizes in the monoclinic system (P21) [a = 15.1337(7), b = 12.2587(5), c = 18.8766(9), and β = 105.811(5)°]. The compound showed selective inhibitory effect against β-glucuronidase enzyme (IC50 3.1 ± 0.1 μM), which is more potent than our standard, d-saccharic acid 1,4-lactone (IC50 48.4 ± 1.3 μM). Also, it exhibited immunomodulatory activity, and cytotoxicity against PC-3 cell line (IC50 = 16.9 ± 1.3 μM, and 1.2 ± 0.1 μM, respectively), which are close to the standards ibuprofen (IC50 11.8 ± 1.8 μM), and doxorubicin (IC50 0.9 ± 0.1 μM), respectively. This compound did not show any significant inhibition for other biological test such as α-chymotrypsin, urease, phosphodiesterase enzymes, and antiglycation activity.

DOI: 10.1007/s00044-011-9916-6

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@article{Ettouhami2011DiorganotinD, title={Diorganotin (IV) derivative of 2-thiophene acetic acid: characterizations and biological activities of \{[n-Bu2SnO2C–CH2–C4H3S]2O\}2}, author={Abdelkader Ettouhami and Abderrahman Yahyi and Abdellah El Mejdoubi and Brahim El Bali and Sadia Siddiq and Sagufta Noureen and Bishnu P. Marasini and Ajmal Khan and Saima Rasheed and Mohammad Iqbal Choudhary}, journal={Medicinal Chemistry Research}, year={2011}, volume={21}, pages={3607-3614} }