Dinutuximab: First Global Approval

@article{Dhillon2015DinutuximabFG,
  title={Dinutuximab: First Global Approval},
  author={Sohita Dhillon},
  journal={Drugs},
  year={2015},
  volume={75},
  pages={923-927}
}
United Therapeutics Corporation and the National Cancer Institute are developing dinutuximab (Unituxin™; ch14.18), a monoclonal antibody targeting GD2, for the treatment of neuroblastoma. GD2 is a glycolipid found on the surface of tumour cells, which is overexpressed in neuroblastoma. Dinutuximab, an IgG1 human/mouse chimeric switch variant of murine monoclonal antibody 14G2a, binds to GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity. The US… CONTINUE READING
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