Dinoprostone Vaginal Insert: A Review in Cervical Ripening

@article{Shirley2018DinoprostoneVI,
  title={Dinoprostone Vaginal Insert: A Review in Cervical Ripening},
  author={Matt Shirley},
  journal={Drugs},
  year={2018},
  volume={78},
  pages={1615-1624}
}
Dinoprostone vaginal insert (Cervidil®; Propess®), a retrievable vaginal pessary containing 10 mg of dinoprostone [prostaglandin E2 (PGE2)] in a controlled-release drug delivery device, is approved in many countries worldwide for the initiation (or continuation) of cervical ripening in patients at term prior to labour induction. The device is designed to provide a constant and sustained release of dinoprostone to the cervix to promote the complex processes involved in cervical ripening. The… Expand
Using dinoprostone vaginal insert for induction of labor: A single institute experience.
TLDR
Dinoprostone slow-released vaginal insert is a good choice for multiparous pregnant women who need IOL, regardless of which reasons are indicated, and more studies might be needed to evaluate the effectiveness of PGE2 for IOL. Expand
Benefits of vaginal dinoprostone administration prior to levonorgestrel-releasing intrauterine system insertion in women delivered only by elective cesarean section: a randomized double-blinded clinical trial
TLDR
Dinoprostone administration 2 h before LNG-IUS insertion in women delivered by elective CD effectively reduced pain during insertion and 30 min post-procedure and women received dinopro stone had easier and shorter insertion and were more satisfied with tolerable side effects. Expand
Is there an interest in repeating the vaginal administration of dinoprostone (Propess®), to promote induction of labor of pregnant women at term? (RE-DINO): study protocol for a randomized controlled trial
TLDR
Re-DINO is a prospective, open-label, multicenter, randomized superiority trial with two parallel arms running in six French hospitals to determine whether placement of a second Propess®, (followed by oxytocin [Syntocinon®], if necessary) in women for whom the first Propess® failed to induce cervical ripening increases the vaginal delivery rate compared to direct Oxytocin injection. Expand
Vaginal dinoprostone versus placebo for pain relief during intrauterine device insertion: a systematic review and meta-analysis of randomized controlled trials
TLDR
This first ever meta-analysis advocates that dinoprostone is safe, effective, and yields favorable analgesic outcomes during IUD insertion. Expand
Benefits of self-administered vaginal dinoprostone 12 hours prior to levonorgestrel-releasing intrauterine device insertion in nulliparous adolescents and young women: A Randomized Controlled Trial.
TLDR
Self-administered dinoprostone 3mg vaginally 12 hours prior to a 52 mg LNG-IUD insertion in nulliparous adolescent and young women effectively reduced pain during insertion and increased women's satisfaction and ease of insertion reported by clinicians. Expand
Vaginal dinoprostone versus placebo for pain relief during intrauterine device insertion: a systematic review and meta-analysis of randomised controlled trials
  • A. Abu-Zaid, M. Alshahrani, +10 authors S. Baradwan
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2021
TLDR
This first ever meta-analysis advocates that dinoprostone compared with placebo is safe, effective, and yields favourable analgesic outcomes during IUD insertion. Expand
Determining the Optimal Time Interval Between Vaginal Dinoprostone Administration and Diagnostic Office Hysteroscopy in Nulliparous Women: A Randomized Double-Blind Trial.
TLDR
Vaginal dinoprostone 12 hours before OH was more effective than vaginal dinobrostone administrated 3 hours beforeOH in reducing pain during OH in nulliparous patients with easier hysteroscope insertion, shorter procedure duration, and better women satisfaction score. Expand
Differences of Increased Bishop Scores Between Neutrophil Swab Vaginal ≤ 5 and > 5 in 41 Weeks of Pregnancy Induced With Misoprostol
TLDR
The purpose of this study was to determine the difference in Bishop score increase between vaginal swab neutrophils ≤ 5 and > 5 in pregnancy ≥ 41 weeks induced by misoprostol. Expand
Intracervical Foley Catheter Plus Intravaginal Misoprostol vs Intravaginal Misoprostol Alone for Cervical Ripening: A Meta-Analysis
TLDR
Labor induction with a combination of intracervical Foley catheter and intravaginal misoprostol may be a better choice based on advantages in shortening induction time and reducing the risk of uterine tachysystole and meconium staining compared to intravagsinal misOProstol alone. Expand
Efficacy and safety of controlled‐release dinoprostone vaginal delivery system (PROPESS) in Japanese pregnant women requiring cervical ripening: Results from a multicenter, randomized, double‐blind, placebo‐controlled phase III study
TLDR
To evaluate the efficacy and safety of dinoprostone vaginal insert in pregnant post‐term Japanese women requiring cervical ripening, PROPESS is evaluated. Expand
...
1
2
...

References

SHOWING 1-10 OF 42 REFERENCES
A comparison of intermittent vaginal administration of misoprostol with continuous dinoprostone for cervical ripening and labor induction.
TLDR
Vaginally administered misoprostol is as effective as dinoprostone for cervical ripening and the induction of labor and mean time intervals to delivery, need for oxytocin augmentation, and routes of delivery were similar between the two groups. Expand
DINOPROSTONE VAGINAL INSERT FOR CERVICAL RIPENING AND LABOR INDUCTION: A META‐ANALYSIS
TLDR
No clinically significant differences were identified between the vaginal insert and alternatives used for cervical ripening at term and their combination is therefore of limited value and potentially misleading. Expand
Efficiency of dinoprostone insert for cervical ripening and induction of labor in women of full-term pregnancy compared with dinoprostone gel: A meta-analysis.
TLDR
Dinoprostone insert showed a distinct superiority in terms of VD within 24 h and had an advantage of a shorter hospital stay and less postpartum hemorrhage in contrast to gel, yet the superior benefit of the vaginal insert compared to gel was still not difficult to observe. Expand
Labor induction with intravaginal misoprostol compared with the dinoprostone vaginal insert: a systematic review and metaanalysis.
TLDR
Vaginally administered misoprostol was more effective than the dinoprostone vaginal insert for cervical ripening and labor induction and the safety profiles of both drugs were similar. Expand
A clinical evaluation of controlled-release dinoprostone for cervical ripening – a review of current evidence in hospital and outpatient settings
  • W. Rath
  • Medicine
  • Journal of perinatal medicine
  • 2005
TLDR
The ease of use of controlled-release dinoprostone and women's satisfaction emphasize its benefits over many other agents used to ripen the cervix, and the efficacy and safety are comparable whether it is used in the outpatient or the inpatient setting. Expand
Misoprostol Vaginal Insert Compared With Dinoprostone Vaginal Insert: A Randomized Controlled Trial
  • D. Wing
  • Medicine
  • Obstetrics and gynecology
  • 2008
TLDR
The misoprostol vaginal insert 100 and the dinoprostone vaginal insert had similar median time intervals to vaginal delivery, whereas the misopral vaginal insert 50 had a significantly longer time to vaginal Delivery. Expand
Can we predict successful cervical ripening with prostaglandin E2 vaginal inserts?
TLDR
Overall, basic parameters, such as parity, cervical dilatation at admission and gestational age can predict successful cervical ripening PGE2 vaginal inserts. Expand
A randomized trial of preinduction cervical ripening: dinoprostone vaginal insert versus double-balloon catheter.
TLDR
The use of a double-balloon catheter for cervical ripening is associated with a higher rate of vaginal birth within 24 hours compared with a PGE2 vaginal insert. Expand
Foley Catheter Compared With the Controlled-Release Dinoprostone Insert: A Randomized Controlled Trial
TLDR
Starting labor inductions with a Foley catheter, compared with the dinoprostone vaginal insert, results in a shorter time to delivery and a higher proportion of women delivered and delivered vaginally within 24 hours. Expand
Misoprostol Vaginal Insert and Time to Vaginal Delivery: A Randomized Controlled Trial
TLDR
Use of a 200-microgram misoprostol vaginal inset significantly reduced times to vaginal delivery and active labor with reduced need for oxytocin compared with the dinoprostone vaginal insert. Expand
...
1
2
3
4
5
...