Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxide.

@article{Bosworth2009DinitrosylironCA,
  title={Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxide.},
  author={Charles A Bosworth and Jos{\'e} Carlos de Toledo and Jaroslaw W Zmijewski and Qian Li and Jack R. Lancaster},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 12},
  pages={4671-6}
}
Nitrosothiols (RSNO), formed from thiols and metabolites of nitric oxide (*NO), have been implicated in a diverse set of physiological and pathophysiological processes, although the exact mechanisms by which they are formed biologically are unknown. Several candidate nitrosative pathways involve the reaction of *NO with O(2), reactive oxygen species (ROS), and transition metals. We developed a strategy using extracellular ferrocyanide to determine that under our conditions intracellular protein… CONTINUE READING
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Nitric oxide and mitochondria

  • GC Brown
  • Front Biosci
  • 2007
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