Dimorphic sequences of rap-1 genes encode B and CD4+ T helper lymphocyte epitopes in the Babesia bigemina rhoptry associated protein-1.

@article{Htzel1996DimorphicSO,
  title={Dimorphic sequences of rap-1 genes encode B and CD4+ T helper lymphocyte epitopes in the Babesia bigemina rhoptry associated protein-1.},
  author={Isidro H{\"o}tzel and Wendy C. Brown and T F Mcelwain and Santiago de Cordoba Rodriguez and Guy H. Palmer},
  journal={Molecular and biochemical parasitology},
  year={1996},
  volume={81 1},
  pages={89-99}
}
The rhoptry-associated protein-1 (RAP-1) of Babesia bigemina induces protective immune responses in cattle and contains neutralization-sensitive B cell epitopes. RAP-1 variants containing blocks of sequence dimorphism in the amino and carboxy terminal ends are encoded by four nonallelic genes in B. bigemina. Epitopes recognized by RAP-1 specific monoclonal antibodies (MAbs) and bovine CD4+ T cell clones were mapped to determine whether these epitopes are localized in the amino and carboxy… CONTINUE READING

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