Dimorphic primers derived from intron 1 for use in the molecular typing of HLA-B alleles.

@article{Cereb1997DimorphicPD,
  title={Dimorphic primers derived from intron 1 for use in the molecular typing of HLA-B alleles.},
  author={Nezih Cereb and Soo Young Yang},
  journal={Tissue antigens},
  year={1997},
  volume={50 1},
  pages={
          74-6
        }
}
We have identified a dimorphic site in intron 1 of the HLA-B gene. Oligotyping was performed on about 3000 samples using primers derived from this dimorphic site in combination with a locus-specific primer derived from intron 3. The distribution of B-alleles bearing each of the dimorphic sequences was approximately equal. These primers were mutually exclusive and yielded approximately 50% of the heterozygous samples as apparently homozygous in PCR products. Intermediate and almost high… CONTINUE READING
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