Dimorphic histopathology of long-standing childhood-onset diabetes

  title={Dimorphic histopathology of long-standing childhood-onset diabetes},
  author={Roberto Gianani and Martha Campbell-Thompson and Suparna A. Sarkar and Clive Wasserfall and Alberto Pugliese and Jorge Solis and Sally C. Kent and Bernhard J. Hering and Emily K. West and Andrea K Steck and Susan Bonner-Weir and Mark A Atkinson and Ken Coppieters and Matthias von G. Herrath and George S. Eisenbarth},
Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity. We evaluated 20 cadaveric organ donor… CONTINUE READING
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C-peptide levels correlate with age of onset, duration of diabetes and autoantibody status. Diabetes 58(Suppl 1):A459 (Abstract

  • KA Steck, L Yu, T Armstrong
  • 2009
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