Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.

@article{Cook2015DimorphicEO,
  title={Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.},
  author={Jason R Cook and Nicholas P Clayton and Luca Carta and Josephine Galatioto and Emily Chiu and Silvia Smaldone and Carol A. Nelson and Seng H. Cheng and B. M. Wentworth and Francesco Ramirez},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 4},
  pages={911-7}
}
OBJECTIVE Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of noncanonical (Erk-mediated) TGFβ signaling by the angiotensin type I receptor (AT1r). This correlation was largely based on comparable TAA modifications by either systemic TGFβ neutralization or AT1r antagonism. However, subsequent investigations have called into question some key aspects of this mechanism of arterial disease in MFS. To resolve… CONTINUE READING