Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming.

@article{Lee2006DimorphicPF,
  title={Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming.},
  author={Edwin A. M. Lee and Katie L Flanagan and Gabriela Minigo and William H. H. Reece and Robin Bailey and Margaret Pinder and Adrian V S Hill and Magdalena Plebanski},
  journal={European journal of immunology},
  year={2006},
  volume={36 5},
  pages={1168-78}
}
The leading blood-stage malaria vaccine candidate antigen, Plasmodium falciparum merozoite surface protein-1 (MSP-1) occurs in two major allelic types worldwide. The molecular basis promoting this stable dimorphism is unknown. In this study, we have shown that allelic altered peptide ligand (APL) T cell epitopes of MSP-1 mutually inhibited IFN-gamma secretion as well as proliferation of CD4+ T cells in 27/34 malaria exposed Gambian volunteers. Besides this inhibition of malaria-specific… CONTINUE READING
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