Diminished survival of human cytotrophoblast cells exposed to hypoxia/reoxygenation injury and associated reduction of heparin-binding epidermal growth factor-like growth factor.

@article{Leach2008DiminishedSO,
  title={Diminished survival of human cytotrophoblast cells exposed to hypoxia/reoxygenation injury and associated reduction of heparin-binding epidermal growth factor-like growth factor.},
  author={Richard E. Leach and Brian A. Kilburn and Anelia P Petkova and Roberto Romero and David Randall Armant},
  journal={American journal of obstetrics and gynecology},
  year={2008},
  volume={198 4},
  pages={471.e1-7; discussion 471.e7-8}
}
OBJECTIVE The antiapoptotic action of heparin-binding epidermal growth factor (HBEGF)-like growth factor and its regulation by O(2) constitutes a key factor for trophoblast survival. The hypothesis that cytotrophoblast survival is compromised by exposure to hypoxia-reoxygenation (H/R) injury, which may contribute to preeclampsia and some missed abortions, prompted us to investigate HBEGF regulation and its role as a survival factor during H/R in cytotrophoblast cells. STUDY DESIGN A… CONTINUE READING
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