Diminished selection for thymidine-analog mutations associated with the presence of M184V in Ethiopian children infected with HIV subtype C receiving lamivudine-containing therapy.

@article{Averbuch2006DiminishedSF,
  title={Diminished selection for thymidine-analog mutations associated with the presence of M184V in Ethiopian children infected with HIV subtype C receiving lamivudine-containing therapy.},
  author={Diana Averbuch and Jonathan M. Schapiro and Ernest Randall Lanier and Serge Gradstein and Giora Gottesman and Eynat Kedem and Menachem Einhorn and Galia Grisaru-Soen and Michal Ofir and Dan Engelhard and Zehava Grossman},
  journal={The Pediatric infectious disease journal},
  year={2006},
  volume={25 11},
  pages={1049-56}
}
BACKGROUND We retrospectively studied the effect of the lamivudine-induced reverse transcription mutation M184V on selection of thymidine analog mutations (TAMs) in HIV subtype C-infected children and on clinical outcome. METHODS We genotyped 135 blood samples from 55 children. TAMs accumulation, viral load and clinical outcome were compared in children… CONTINUE READING