Diminished rev-mediated stimulation of human immunodeficiency virus type 1 protein synthesis is a hallmark of human astrocytes.

@article{Ludwig1999DiminishedRS,
  title={Diminished rev-mediated stimulation of human immunodeficiency virus type 1 protein synthesis is a hallmark of human astrocytes.},
  author={Elisabeth Ludwig and Francesca Ceccherini Silberstein and J van Empel and Volker Erfle and Marc Neumann and Ruth Brack-Werner},
  journal={Journal of virology},
  year={1999},
  volume={73 10},
  pages={8279-89}
}
Astrocytes are target cells for human immunodeficiency virus type 1 (HIV-1) in the central nervous system with attenuated virus replication in vivo and in vitro. In infected astrocytes, viral gene expression is restricted mainly to nonstructural (early) viral components like Nef, suggesting inhibition of Rev-dependent posttranscriptional processes in these cells. Because of the heterogeneity of astrocytic cells, the objective of this study was to determine whether restriction of HIV-1 Rev… CONTINUE READING

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