Diminished renal kallikrein responses to mineralocorticoid stimulation in African Americans: determinants of an intermediate phenotype for hypertension.

@article{Wong2003DiminishedRK,
  title={Diminished renal kallikrein responses to mineralocorticoid stimulation in African Americans: determinants of an intermediate phenotype for hypertension.},
  author={Caroline M. Wong and Daniel T. O'Connor and J. A Prohias Martinez and Mala T. Kailasam and Robert J. Parmer},
  journal={American journal of hypertension},
  year={2003},
  volume={16 4},
  pages={
          281-9
        }
}
BACKGROUND Hypertension is a complex trait with an ill-defined genetic predisposition, in which renal mechanisms seem to be involved even at the early stages. Renal kallikrein excretion is diminished in patients with hypertension, and perhaps even in the early, prehypertensive phases of the syndrome. African Americans, a group at increased risk of developing hypertension, have especially diminished kallikrein expression, coupled with decreased renal excretion of K(+), a known stimulant of… CONTINUE READING
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