Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction.

@article{Kim2001DiminishedRE,
  title={Diminished renal expression of aquaporin water channels in rats with experimental bilateral ureteral obstruction.},
  author={Soo Wan Kim and Sung Hee Cho and Byung Seok Oh and Chung Ho Yeum and Ki Chul Choi and Kyu Youn Ahn and Jong Un Lee},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 10},
  pages={2019-28}
}
Whether postobstructive diuresis could be related to altered regulation of aquaporin (AQP) water channels in the kidney was investigated. Male Sprague-Dawley rats underwent bilateral obstruction of the proximal ureters for 48 h. The renal expression of AQP1 to AQP4 proteins was then determined by Western blot and immunohistochemical analyses. For elucidation of the primary impairment in the upstream pathway leading to the expression of cAMP-mediated AQP channels, the expression of G(salpha) and… CONTINUE READING
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