Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice.

  title={Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice.},
  author={Ruth Lucas and Samer S Hattar and Motoharu Takao and David M. Berson and Russel G. Foster and K W Yau},
  volume={299 5604},
In the mammalian retina, a small subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, express the opsin-like protein melanopsin, and project to brain nuclei involved in non-image-forming visual functions such as pupillary light reflex and circadian photoentrainment. We report that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections… CONTINUE READING
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