Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis.

@article{Maher2010DiminishedPE,
  title={Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis.},
  author={Toby M Maher and Iona C. Evans and Stephen E. W. Bottoms and Paul F. Mercer and Andrew J. Thorley and Andrew G. Nicholson and Geoffrey John Laurent and Teresa D. Tetley and Rachel C Chambers and Robin J McAnulty},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={182 1},
  pages={
          73-82
        }
}
RATIONALE Patients with idiopathic pulmonary fibrosis (IPF), a progressive disease with a dismal prognosis, exhibit an unexplained disparity of increased alveolar epithelial cell (AEC) apoptosis but reduced fibroblast apoptosis. OBJECTIVES To examine whether the failure of patients with IPF to up-regulate cyclooxygenase (COX)-2, and thus the antifibrotic mediator prostaglandin (PG)E(2), accounts for this imbalance. METHODS Fibroblasts and primary type II AECs were isolated from control and… CONTINUE READING
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