Diminished phospholipase C activation by dopamine in spontaneously hypertensive rats.

@article{Chen1992DiminishedPC,
  title={Diminished phospholipase C activation by dopamine in spontaneously hypertensive rats.},
  author={C. J. Chen and Subhash J. Vyas and Joseph Eichberg and Mustafa F. Lokhandwala},
  journal={Hypertension},
  year={1992},
  volume={19 1},
  pages={102-8}
}
It is reported that a defect in dopamine-1 (DA-1) receptor adenylate cyclase coupling in the proximal convoluted tubule in the spontaneously hypertensive rat may contribute to the diminished natriuretic response to DA-1 receptor agonists. Since the tubular DA-1 receptor is also coupled to phospholipase C, and both of these cellular signaling processes are involved in DA-1 receptor-mediated diuresis and natriuresis, it is important to know whether a similar defect is also present in DA-1… CONTINUE READING