Diminished percentage of CD4+ T-lymphocytes expressing interleukine-2 receptor alpha in chronic brucellosis.

@article{Skendros2007DiminishedPO,
  title={Diminished percentage of CD4+ T-lymphocytes expressing interleukine-2 receptor alpha in chronic brucellosis.},
  author={Panagiotis Skendros and Panagiota Boura and Dimitrios Chrisagis and Maria Raptopoulou-Gigi},
  journal={The Journal of infection},
  year={2007},
  volume={54 2},
  pages={192-7}
}
OBJECTIVES AND METHODS Despite the treatment, a considerable proportion of brucellosis patients develop chronic disease, characterized by atypical clinical picture and/or relapses. Th1 cytokines are critical for the clearance of Brucella infection and diminished production of IL-2 in response to PHA, has been described in chronic brucellosis. In order to investigate the role of IL-2R alpha (CD25) in disease outcome, we evaluated the ex vivo and PHA-induced percentage of peripheral CD4+ T… CONTINUE READING
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