Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction

@article{ODell2006DiminishedNW,
  title={Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction},
  author={Laura E. O’Dell and Adie W. Bruijnzeel and Ron T. Smith and Loren Howell Parsons and Michele L. Merves and Bruce A. Goldberger and Heather N Richardson and George F. Koob and A. Markou},
  journal={Psychopharmacology},
  year={2006},
  volume={186},
  pages={612-619}
}
Enhanced reinforcing effects of nicotine during adolescence appear to contribute to the rapid development of dependence in this age group. However, the contribution of nicotine withdrawal to dependence in adolescents is unclear. We compared motivational and somatic signs of nicotine withdrawal in adolescent and adult rats. In experiment 1, motivational signs of nicotine withdrawal were compared using intracranial self-stimulation procedures after administration of mecamylamine (1.5 mg/kg, i.p… CONTINUE READING
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