Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects.

@article{Ruiz2016DiminishedLO,
  title={Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects.},
  author={Aleida N{\'u}{\~n}ez Ruiz and Juan Diego Cort{\'e}s-Garc{\'i}a and Nancy Cortez-Espinosa and Paola Indira Herrera-Rojas and V{\'i}ctor Manuel Ru{\'i}z-Rodr{\'i}guez and Mariana Salgado-Bustamante and Mariana Haydee Garc{\'i}a-Hern{\'a}ndez and Elizabeth Reynaga-Hern{\'a}ndez and Ver{\'o}nica Del Carmen Mart{\'i}nez-Jim{\'e}nez and Diana Patricia Portales-P{\'e}rez},
  journal={Nutrition},
  year={2016},
  volume={32 9},
  pages={943-54}
}
OBJECTIVES The aim of this study was to identify regulatory T cell (Treg) subsets residing in adipose tissue, demonstrate their immunosuppressive functions, and assess the possible role of Sirt1 in their function in overweight subjects. METHODS Fat samples were obtained by lipoaspiration from healthy overweight (n = 15) and normoweight (n = 11) subjects. We obtained the stromal vascular fraction and then isolated the mononuclear cells by Ficoll-Hypaque sedimentation. The Treg subsets were… CONTINUE READING