Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair.

@article{Liechty2000DiminishedI6,
  title={Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair.},
  author={Kenneth W. Liechty and N. Scott Adzick and Timothy M. Crombleholme},
  journal={Cytokine},
  year={2000},
  volume={12 6},
  pages={671-6}
}
Fetal wound healing is characterized by minimal inflammation and scarless repair. IL-6 stimulates inflammation in postnatal wound healing. We hypothesized that fetal skin has a diminished IL-6 response and that exogenous IL-6 will result in scar formation. Human adult or fetal skin was placed subcutaneously in SCID mice and incisionally wounded. Wounds were excised after 4, 12, 24 or 72 h for IL-6 mRNA quantification by RT-PCR. In other grafts, 5 microgram of IL-6 was injected at wounding and… CONTINUE READING

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