Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF‐1 gene dosage

@article{Tran2006DiminishedHB,
  title={Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF‐1 gene dosage},
  author={P. Tran and S. Akana and I. Malkovska and M. Dallman and L. Parada and H. Ingraham},
  journal={Journal of Comparative Neurology},
  year={2006},
  volume={498}
}
  • P. Tran, S. Akana, +3 authors H. Ingraham
  • Published 2006
  • Medicine, Biology
  • Journal of Comparative Neurology
  • In the central nervous system, steroidogenic factor 1 (SF‐1) is required for terminal differentiation of neurons within the ventromedial hypothalamus (VMH). Given the importance of this brain region in regulating physiological homeostasis including energy balance, we asked how sf‐1 gene dosage affects VMH function. Despite an apparent normal VMH cytoarchitecture, sf‐1 heterozygous (+/−) mice exhibited diet‐induced obesity when they were group housed with hyperphagia and impaired sympathetic… CONTINUE READING
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