Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.

@article{Tran2006DiminishedHB,
  title={Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.},
  author={Phu V. Tran and Susan F. Akana and Irena Malkovska and Mary F. Dallman and Luis F. Parada and Holly A. Ingraham},
  journal={The Journal of comparative neurology},
  year={2006},
  volume={498 5},
  pages={637-48}
}
In the central nervous system, steroidogenic factor 1 (SF-1) is required for terminal differentiation of neurons within the ventromedial hypothalamus (VMH). Given the importance of this brain region in regulating physiological homeostasis including energy balance, we asked how sf-1 gene dosage affects VMH function. Despite an apparent normal VMH cytoarchitecture, sf-1 heterozygous (+/-) mice exhibited diet-induced obesity when they were group housed with hyperphagia and impaired sympathetic… CONTINUE READING
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