Diminished expression of CD40 ligand by activated neonatal T cells.

@article{Nonoyama1995DiminishedEO,
  title={Diminished expression of CD40 ligand by activated neonatal T cells.},
  author={Shigeaki Nonoyama and Laurie A Penix and Caroline P Edwards and David B Lewis and Shuji Ito and Alejandro Aruffo and Curtis B. Wilson and Hans D. Ochs},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 1},
  pages={66-75}
}
CD40 and CD40 ligand (gp39) mediate contact-dependent T-B cell interaction. We determined the expression of CD40 ligand by activated neonatal T cells and the response of neonatal B cells when activated through CD40. Although expression of CD40 ligand peaked simultaneously in both activated adult and neonatal cells, neonatal T cells expressed significantly less CD40 ligand surface protein and mRNA than adult T cells. Activated thymocytes also expressed far less CD40 ligand than adult T cells… CONTINUE READING

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