Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation.

@article{Babu2005DiminishedEA,
  title={Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation.},
  author={Subash Babu and Carla P. Blauvelt and Vasanthapuram Kumaraswami and Thomas B Nutman},
  journal={Journal of immunology},
  year={2005},
  volume={175 2},
  pages={1170-6}
}
Lymphatic filariasis is a disease characterized by immune dysregulation involving APC and T cell populations. To assess the contribution of TLR in mediating this dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of filaria-infected and uninfected individuals. Baseline expression of TLR was significantly lower in B cells but not in monocytes of the filaria-infected group compared with the uninfected group. Upon stimulation with filarial Ag, a… CONTINUE READING

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