Diminished energy metabolism and enhanced apoptosis in livers of B6C3F1 mice treated with the antihepatocarcinogen rotenone

@article{Wang1999DiminishedEM,
  title={Diminished energy metabolism and enhanced apoptosis in livers of B6C3F1 mice treated with the antihepatocarcinogen rotenone},
  author={C. Wang and Jihan Youssef and Beg{\"u}m Saran and Paul G. Rothberg and Michael L. Cunningham and Agostino Molteni and Mostafa Badr},
  journal={Molecular and Cellular Biochemistry},
  year={1999},
  volume={201},
  pages={25-32}
}
Rotenone decreases the incidence of hepatocellular carcinoma and lowers rates of hepatocellular proliferation. In an effort to delineate mechanisms involved, the in vivo effect of rotenone on liver mitochondrial metabolism, apoptotic machinery as well as elements of the hepatic signal transduction pathways were investigated. Mitochondria from livers of male B6C3F1 mice fed a standard diet containing 600 ppm rotenone for 7 days were uncoupled or inhibited when succinate or glutamate plus malate… CONTINUE READING
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