Diminished contact hypersensitivity response in IL-4 deficient mice at a late phase of the elicitation reaction.

@article{Weigmann1997DiminishedCH,
  title={Diminished contact hypersensitivity response in IL-4 deficient mice at a late phase of the elicitation reaction.},
  author={Benno Weigmann and Jens Schwing and Heinz Huber and R. Ross and Horst Mossmann and Juergen Knop and Angelika Reske-Kunz},
  journal={Scandinavian journal of immunology},
  year={1997},
  volume={45 3},
  pages={308-14}
}
Contact hypersensitivity (CHS) is thought to depend on the activation of T cells of Th1 and/or Tc1 type. The role of Th2/Tc2 cells in the contact allergic reaction is not clear. The aim of this study was to analyse the functional contribution of Th2/Tc2 cells in CHS using the interleukin-4 (IL-4) deficient mouse model. Interleukin-4 deficient (IL4T) and control (wt) mice were sensitized by epicutaneous application of 2,4-dinitrofluorobenzene. The ear swelling response measured 24 h after… CONTINUE READING

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