Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing.

@article{Ekholm2002DiminishedCS,
  title={Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing.},
  author={Erika Ekholm and Kurt D. Hankenson and Hannele Uusitalo and Ari Hiltunen and Humphrey Gardner and Jyrki Heino and Risto Penttinen},
  journal={The American journal of pathology},
  year={2002},
  volume={160 5},
  pages={1779-85}
}
Integrins mediate cell adhesion to extracellular matrix components. Integrin alpha 1 beta 1 is a collagen receptor expressed on many mesenchymal cells, but mice deficient in alpha 1 integrin (alpha1-KO) have no gross structural defects. Here, the regeneration of a fractured long bone was studied in alpha1-KO mice. These mice developed significantly less callus tissue than the wild-type (WT) mice, and safranin staining revealed a defect in cartilage formation. The mRNA levels of nine… CONTINUE READING

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