Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration

@article{Painter2014DiminishedSC,
  title={Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration},
  author={Michio W. Painter and Amanda Brosius Lutz and Y Cheng and Alban Latr{\'e}moli{\`e}re and Kelly Duong and Christine Marie Miller and Sean Posada and Enrique Jos{\'e} Cobos and Alice H. X. Zhang and Amy J Wagers and Leif A Havton and Ben Barres and Takao Omura and Clifford J Woolf},
  journal={Neuron},
  year={2014},
  volume={83},
  pages={331-343}
}
  • Michio W. Painter, Amanda Brosius Lutz, +11 authors Clifford J Woolf
  • Published in Neuron 2014
  • Biology, Medicine
  • The regenerative capacity of the peripheral nervous system declines with age. Why this occurs, however, is unknown. We demonstrate that 24-month-old mice exhibit an impairment of functional recovery after nerve injury compared to 2-month-old animals. We find no difference in the intrinsic growth capacity between aged and young sensory neurons in vitro or in their ability to activate growth-associated transcriptional programs after injury. Instead, using age-mismatched nerve transplants in vivo… CONTINUE READING

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