Diminished Perisomatic GABAergic Terminals on Cortical Neurons Adjacent to Amyloid Plaques

@inproceedings{GarcaMarn2009DiminishedPG,
  title={Diminished Perisomatic GABAergic Terminals on Cortical Neurons Adjacent to Amyloid Plaques},
  author={Virginia Garc{\'i}a-Mar{\'i}n and Lidia Blazquez-Llorca and Jos{\'e}-Rodrigo Rodr{\'i}guez and Susana Boluda and Gerard Muntan{\'e} and Isidro Ferrer and Javier DeFelipe},
  booktitle={Front. Neuroanat.},
  year={2009}
}
One of the main pathological hallmarks of Alzheimer's disease (AD) is the accumulation of plaques in the cerebral cortex, which may appear either in the neuropil or in direct association with neuronal somata. Since different axonal systems innervate the dendritic (mostly glutamatergic) and perisomatic (mostly GABAergic) regions of neurons, the accumulation of plaques in the neuropil or associated with the soma might produce different alterations to synaptic circuits. We have used a variety of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 93 REFERENCES

The proximity of excitatory and inhibitory perisomatic axon terminals provides the basis for putative cortical nonsynaptic interactions

A. Merchan-Perez, J. R. Rodriguez, C. E. Ribak, J. DeFelipe
  • Proc . Natl . Acad . Sci . U . S . A .
  • 2009
VIEW 1 EXCERPT