Diminished Ost3-dependent N-glycosylation of the BiP nucleotide exchange factor Sil1 is an adaptive response to reductive ER stress.

Abstract

BiP (Kar2 in yeast) is an essential Hsp70 chaperone and master regulator of endoplasmic reticulum (ER) function. BiP's activity is regulated by its intrinsic ATPase activity that can be stimulated by two different nucleotide exchange factors, Sil1 and Lhs1. Both Sil1 and Lhs1 are glycoproteins, but how N-glycosylation regulates their function is not known… (More)
DOI: 10.1073/pnas.1705641114

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@article{Stevens2017DiminishedON, title={Diminished Ost3-dependent N-glycosylation of the BiP nucleotide exchange factor Sil1 is an adaptive response to reductive ER stress.}, author={Kofi L P Stevens and Amy L Black and Kelsi M Wells and K Y Benjamin Yeo and Robert F L Steuart and C. J. Stirling and Benjamin L Schulz and Carl J. Mousley}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2017}, volume={114 47}, pages={12489-12494} }