Diminished Neural Processing of Aversive and Rewarding Stimuli During Selective Serotonin Reuptake Inhibitor Treatment

@inproceedings{McCabe2010DiminishedNP,
  title={Diminished Neural Processing of Aversive and Rewarding Stimuli During Selective Serotonin Reuptake Inhibitor Treatment},
  author={Ciara McCabe and Zevic Mishor and Philip J. Cowen and Catherine J. Harmer},
  booktitle={Biological Psychiatry},
  year={2010}
}
BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are popular medications for anxiety and depression, but their effectiveness, particularly in patients with prominent symptoms of loss of motivation and pleasure, has been questioned. There are few studies of the effect of SSRIs on neural reward mechanisms in humans. METHODS We studied 45 healthy participants who were randomly allocated to receive the SSRI citalopram, the noradrenaline reuptake inhibitor reboxetine, or placebo for 7… CONTINUE READING
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