Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism

  title={Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism},
  author={St. Sz{\'a}ra},
  • S. Szára
  • Published 2005
  • Biology, Medicine
  • Experientia
Es wird festgestellt, dass Dimethyltryptamin — bei normalen Versuchspersonen — eine dem Meskalin und dem LSD-25 ähnliche psychotische Wirkung hat. Der durch Dimethyltryptamin induzierte Zustand beginnt schon 3–5 min nach Injektion und verschwindet bereits nach 1 h. Der Urin der Versuchspersonen wurde papier-chromatographisch und kolorimetrisch auf Indolverbindungen geprüft. 3-Indolylessigsäure wird als hauptsächlichstes Abbauprodukt des Dimethyltryptamins gefunden, wovon der grösste Teil in… Expand
The effect of antiserotonin on the experimental psychosis induced by dimethyltryptamine
Dies könnte die bekannte Theorie unterstützen, wonach der psychomimetische Effekt der halluzinogenen Stoffe, wenigstens teilweise, auf Antiserotoninwirkungen beruhen soll. Expand
Dimethyltryptamine: Endogenous Role and Therapeutic Potential
While the role of endogenous DMT remains unclear, ayahuasca has promising results in anxiety, depression and substance dependence, and it is crucial to conduct further research aimed at developing new treatments for psychiatric disorders. Expand
Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects
Psychoactive doses of the hallucinogen N,N-dimethyltryptamine were administered intramuscularly to 11 normal subjects and the blood DMT concentrations had a very similar time course o the subjectively reported “high”. Expand
Cult-Hoasca: A Model for Schizophrenia.
The experimental psychosis observed after drinking Hoasca reproduces the pathologic transmethylation theory of schizophrenia and confirms that the urinary hallucinogenic compounds detected in healthy subjects (post-Hoasca) are the same as those found in the urine samples of acute psychotic unmedicated patients. Expand
Participation of retinal mechanisms in DMT hallucinations
Die Befunde sprechen für eine Beteiligung retinaler Mechanismen beim Zustandekommen optischer Halluzinationen and lassen 5-HT als retinalen Transmitter vermuten. Expand
Neuropharmacology of N,N-dimethyltryptamine
DMT appears to have limited neurotoxicity and other adverse effects except for intense cardiovascular effects when administered intravenously in large doses, and may be a useful experimental tool in exploring how the brain works and a useful clinical tool for treatment of anxiety and psychosis. Expand
Metabolism and urinary disposition of N,N-dimethyltryptamine after oral and smoked administration: a comparative study.
Findings show that in the smoked route a shift from the highly efficient MAO-dependent to the less efficient CYP-dependent metabolism takes place, which leads to psychoactivity and is analogous to that observed in ayahuasca preparations combining DMT with MAO inhibitors. Expand
Hydroxylation and N-demethylation of N,N-dimethyltryptamine
An weiteren Stoffwechselprodukten wurden nachgewiesen: N,N-Dimethyltryptamin-N-oxyd und sein 6-Hydroxy-Derivat (in vitro), sowie Tryptamin, Indol-3-essigsäure und 6-hydroxyindol- 3-essigäure (in vivo). Expand
Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine.
It is proposed that endogenous DMT interacts with the TA receptor to produce a calm and relaxed mental state, which may suppress, rather than promote, symptoms of psychosis, and amphetamine action at the TA receptors may contribute to the calming effects of amphetamine and related drugs, especially at low doses. Expand
N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function
  • S. Barker
  • Biology, Medicine
  • Front. Neurosci.
  • 2018
This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brainExpand


Evidence that serotonin has a role in brain function.
Action of Parapyruvate on Early Development of Strongylocentrotus Purpuratus: C. M. Montgomery and J. W. Bamberger .... ............ 967 Evidence That Serotonin Has a Role in Brain Function: B. B.Expand
Observations on the fate of indolalkylamines in the organism
  • V. Erspamer
  • Chemistry, Medicine
  • The Journal of physiology
  • 1955
Oxidative N-dealkylation.
Kongress Miinchen, 25. bis 29
  • ZmNDE~ und A. STVDER