Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism

@article{Szra2005DimethyltryptaminIM,
  title={Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism},
  author={St. Sz{\'a}ra},
  journal={Experientia},
  year={2005},
  volume={12},
  pages={441-442}
}
  • S. Szára
  • Published 15 November 1956
  • Biology, Medicine
  • Experientia
Es wird festgestellt, dass Dimethyltryptamin — bei normalen Versuchspersonen — eine dem Meskalin und dem LSD-25 ähnliche psychotische Wirkung hat. Der durch Dimethyltryptamin induzierte Zustand beginnt schon 3–5 min nach Injektion und verschwindet bereits nach 1 h. Der Urin der Versuchspersonen wurde papier-chromatographisch und kolorimetrisch auf Indolverbindungen geprüft. 3-Indolylessigsäure wird als hauptsächlichstes Abbauprodukt des Dimethyltryptamins gefunden, wovon der grösste Teil in… 
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Dies könnte die bekannte Theorie unterstützen, wonach der psychomimetische Effekt der halluzinogenen Stoffe, wenigstens teilweise, auf Antiserotoninwirkungen beruhen soll.
Dimethyltryptamine: Endogenous Role and Therapeutic Potential
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While the role of endogenous DMT remains unclear, ayahuasca has promising results in anxiety, depression and substance dependence, and it is crucial to conduct further research aimed at developing new treatments for psychiatric disorders.
Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects
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Psychoactive doses of the hallucinogen N,N-dimethyltryptamine were administered intramuscularly to 11 normal subjects and the blood DMT concentrations had a very similar time course o the subjectively reported “high”.
Participation of retinal mechanisms in DMT hallucinations
TLDR
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Neuropharmacology of N,N-dimethyltryptamine
Metabolism and urinary disposition of N,N-dimethyltryptamine after oral and smoked administration: a comparative study.
TLDR
Findings show that in the smoked route a shift from the highly efficient MAO-dependent to the less efficient CYP-dependent metabolism takes place, which leads to psychoactivity and is analogous to that observed in ayahuasca preparations combining DMT with MAO inhibitors.
Hydroxylation and N-demethylation of N,N-dimethyltryptamine
TLDR
An weiteren Stoffwechselprodukten wurden nachgewiesen: N,N-Dimethyltryptamin-N-oxyd und sein 6-Hydroxy-Derivat (in vitro), sowie Tryptamin, Indol-3-essigsäure und 6-hydroxyindol- 3-essigäure (in vivo).
Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine.
N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function
This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain
DMT ( N , N-DIMETHYLTRYPTAMINE ) AND HOMOLOGUES : CLINICAL AND PHARMACOLOGICAL CONSIDERATIONS
During the past 13 years we have been working on the biochemistry and pharmacology of the various N-alkylated tryptamine derivatives, both in man and in animals. Interest in the possible
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