Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells.

@article{Lee2005DimethylsulfoxideIU,
  title={Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells.},
  author={Young-Rae Lee and Hyun-Jaung Shim and H Yu and E. Song and Jinny Park and Kang-beom Kwon and Jin-Woo Park and Hye-Won Rho and Byung-Hyun Park and Myung Kwan Han and J. Kim},
  journal={Leukemia research},
  year={2005},
  volume={29 4},
  pages={401-5}
}
Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN with unaffecting the expression of PI3K. The upregulation of PTEN by DMSO lead to the decrease of Akt phosphorylation, a downstream of PI3K. The DMSO-induced upregulation of PTEN might be mediated by… CONTINUE READING

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