Dimethylsulfoniopropionate biosynthesis in marine bacteria and identification of the key gene in this process

  title={Dimethylsulfoniopropionate biosynthesis in marine bacteria and identification of the key gene in this process},
  author={Andrew R. J. Curson and Ji Liu and Ana Bermejo Mart{\'i}nez and Robert T. Green and Yohan Chan and Ornella Carri{\'o}n and Beth T. Williams and Shenghui Zhang and Gui‐Peng Yang and Philip C. Bulman Page and Xiaohua Zhang and Jonathan D. Todd},
  journal={Nature Microbiology},
Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and affects the Earth's albedo, and potentially climate, via sulfate aerosol and cloud condensation nuclei production5,6. It was thought that only eukaryotes produce significant amounts… 
Recent insights into oceanic dimethylsulfoniopropionate biosynthesis and catabolism.
Dimethylsulfoniopropionate (DMSP), a globally important organosulfur compound is produced in prodigious amounts (2.0 Pg sulfur) annually in the marine environment by phytoplankton, macroalgae,
DSYB catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton
Identification of functional dsyB gene homologues for dimethylsulfoniopropionate production in eukaryotic phytoplankton allows estimation of the relative contributions of eUKaryotes and prokaryotes to the global pool, and indicates that this enzyme originated in bacteria.
Novel Insights Into Bacterial Dimethylsulfoniopropionate Catabolism in the East China Sea
Gene probes to the DMSP demethylation gene dmdA and theDMSP lyase gene dddP demonstrated that these DMSP-degrading genes are abundant and widely distributed in ECS seawaters, further confirming the link between this abundant bacterial class and the environmental DMSP cycling.
Bacteria are important dimethylsulfoniopropionate producers in coastal sediments
It is shown that DMSP concentrations and/or rates of DMSP and DMS synthesis are higher in surface sediment from, for example, saltmarsh ponds, estuaries and the deep ocean than in the overlying seawater, and that coastal and marine sediments are important sources of this climate-relevant metabolite.
Evolution of Dimethylsulfoniopropionate Metabolism in Marine Phytoplankton and Bacteria
Experimental evidence is covered supporting the hypothesis that, as DMSP became more readily available in the marine environment, marine bacteria adapted enzymes already encoded in their genomes to utilize this new compound.
Mechanistic insight into DsyB/DSYB, key enzymes in marine dimethylsulfoniopropionate synthesis
Jonathan Todd (  jonathan.todd@uea.ac.uk ) University of East Anglia https://orcid.org/0000-0003-0777-9312 Chun-Yang Li Ocean University of China Jason Crack University of East Anglia Simone
DMSP Production by Coral-Associated Bacteria
Dimethylsulfoniopropionate (DMSP) is an important molecule in the marine sulfur cycle, produced in large amounts by corals and their dinoflagellate endosymbionts, Symbiodiniaceae. Although corals are
Dimethylsulfoniopropionate Sulfur and Methyl Carbon Assimilation in Ruegeria Species
Using an isotopic labeling strategy, it is demonstrated that the direct capture of methanethiol is not the primary pathway used for methionine biosynthesis in two Ruegeria species, a genus comprised primarily of globally abundant marine bacteria.
Oceanospirillales containing the DMSP lyase DddD are key utilisers of carbon from DMSP in coastal seawater
Background Ubiquitous and diverse marine microorganisms utilise the abundant organosulfur molecule dimethylsulfoniopropionate (DMSP), the main precursor of the climate-active gas dimethylsulfide
Biogenic production of DMSP and its degradation to DMS—their roles in the global sulfur cycle
The global distribution pattern of DMSP and DMS, the known genes for biosynthesis and cleavage ofDMSP, and the physiological and ecological functions of these important organosulfur molecules are described, which will improve understanding of the mechanisms of DM SP and D MS production and their roles in the environment.


A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments.
The discovery and characterization of the first gene for DMSP-independent DMS production in any bacterium, mddA, encodes a methyltransferase that methylates methanethiol and generates DMS.
A new route for synthesis of dimethylsulphoniopropionate in marine algae
In vivo isotope labelling is used to demonstrate that DMSP synthesis in the green macroalga Enteromorpha intestinalis proceeds by a route entirely distinct from that in higher plants, and the fact that a transamination initiates this pathway could help explain how algal DMSP production is enhanced by nitrogen deficiency.
Dimethylsulfoniopropionate: Its Sources, Role in the Marine Food Web, and Biological Degradation to Dimethylsulfide
  • D. C. Yoch
  • Environmental Science
    Applied and Environmental Microbiology
  • 2002
This article is more comprehensive, as it includes some of the earlier literature in describing the sources of DMSP, its release and linkage to the marine (primarily microbial) food web and subsequent degradation via cleavage to DMS and acrylic acid or demethylation and demethiolation to methanethiol.
Catabolism of dimethylsulphoniopropionate: microorganisms, enzymes and genes
How recent genetic and genomic work on the ways in which several different bacteria, and some fungi, catabolize DMSP has provided new and surprising insights into the mechanisms, regulation and possible evolution of DMSP catabolism in microorganisms is described.
DMSP biosynthesis by an animal and its role in coral thermal stress response
The results overturn the paradigm that photosynthetic organisms are the sole biological source of DMSP, and highlight the double jeopardy represented by worldwide declining coral cover, as the potential to alleviate thermal stress through coral-produced DMSP declines correspondingly.
An antioxidant function for DMSP and DMS in marine algae
Results show that oxidative stressors, solar ultraviolet radiation, CO2 limitation, Fe limitation, high Cu2+ and H2O2 substantially increased cellular DMSP and/or its lysis to DMS in marine algal cultures, which probably influence the production of DMS and its release to the atmosphere.
The effects of sulfur and sodium concentrations on the uptake and synthesis of DMSHB and DMSP were examined in a sterile mutant of Ulva pertusa Kjellm to demonstrate the importance of MTHB S‐methyltransferase activity and uptake of D MSHB for the regulation of DMSP.
DddQ, a novel, cupin-containing, dimethylsulfoniopropionate lyase in marine roseobacters and in uncultured marine bacteria.
Ruegeria pomeroyi DSS-3, a marine roseobacter, can catabolize dimethylsulfoniopropionate, a compatible solute that is made in large amounts by marine plankton and algae, and has two different genes, dddP and dddQ, which encode enzymes that cleave DMSP, generating DMS plus acrylate.
Molecular dissection of bacterial acrylate catabolism--unexpected links with dimethylsulfoniopropionate catabolism and dimethyl sulfide production.
This first description of genes involved in acrylate catabolism in any organism shows that the relationship between the catabolic pathways of acrylated and DMSP differs from that which had been suggested in other bacteria.