Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549 cells in a synergistic manner.

@article{Uzunova2019DimethylsphingosineAM,
  title={Dimethylsphingosine and miltefosine induce apoptosis in lung adenocarcinoma A549 cells in a synergistic manner.},
  author={V. Uzunova and R. Tzoneva and T. Stoyanova and R. Pankov and R. Skrobanska and G. Georgiev and L. Maslenkova and Zlatan Tsonchev and A. Momchilova},
  journal={Chemico-biological interactions},
  year={2019},
  pages={
          108731
        }
}
Lung cancer is one of the most common and lethal types of oncological diseases. Despite the advanced therapeutic approaches, the prognosis for lung cancer still remains poor. Apparently, there is an imperative need for more efficient therapeutic strategies. In this work we report that concurrent treatment of human adenocarcinoma A549 cells with specific concentrations of two antitumor agents, the sphingosine kinase 1 inhibitor N, N dimethylsphingosine (DMS) and the alkylphosphocholine… Expand
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