Dimethylnitrosamine-induced structural damage to DNA results from repair of O6-methylguanine rather than repair of 7-methylguanine.

@article{Huang1978DimethylnitrosamineinducedSD,
  title={Dimethylnitrosamine-induced structural damage to DNA results from repair of O6-methylguanine rather than repair of 7-methylguanine.},
  author={Paul H. Huang and Bernard W. Stewart},
  journal={Cancer letters},
  year={1978},
  volume={5 3},
  pages={161-6}
}
DNA isolated from the livers of rats treated with a non-necrotizing dose of [14C]dimethylnitrosamine was fractionated by chromatography of benzoylated-DEAE-cellulose. The preparations of native DNA and DNA containing single stranded regions were then hydrolysed and amounts of methylated guanine determined. Four hours after dimethylnitrosamine treatment… CONTINUE READING