Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.

  title={Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.},
  author={Joseph George and Kancharapu Ramachandra Rao and Robert Stern and Gowri Chandrakasan},
  volume={156 2-3},
Dimethylnitrosamine (DMN) is a potent hepatotoxin that can cause fibrosis of the liver. It's ability to provide a suitable rapid experimental murine model for early human cirrhosis was examined. The drug was administered to adult male albino rats in order to document sequential pathological and biochemical alterations. Injury was produced by intraperitoneal injections of DMN on three consecutive days of each week over a 3-week period. A rapid increase in collagen content was documented, with… CONTINUE READING
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