Dimethylfumarate is a potent inducer of apoptosis in human T cells.

  title={Dimethylfumarate is a potent inducer of apoptosis in human T cells.},
  author={Felix Treumer and Kejian Zhu and Regine Glaeser and Ulrich Mrowietz},
  journal={The Journal of investigative dermatology},
  volume={121 6},
Fumaric acid esters (FAE) have been used for the systemic treatment of psoriasis in Germany for almost 50 years. Recently, it has been shown that dimethylfumarate (DMF) as the main ingredient of the marketed FAE mixture is a potent inhibitor of the nuclear transcription factor NF-kappaB. DMF was also shown to induce apoptosis in various cells. Because T cells play a crucial role in psoriasis pathogenesis, we asked whether DMF and its main metabolite methylhydrogenfumarate (MHF) were able to… CONTINUE READING
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