Dimethylarsinic acid (DMA(V) ) changed the expressions of proliferative related factors and secretion of inflammatory cytokines in rat bladder.

@article{Lin2015DimethylarsinicA,
  title={Dimethylarsinic acid (DMA(V) ) changed the expressions of proliferative related factors and secretion of inflammatory cytokines in rat bladder.},
  author={Zhang Lin and Liu Shengnan and Wang Fei and Song Yingli and Sun Qingshan and Sheng Wei and Xi Shuhua and Sun Guifan},
  journal={Journal of applied toxicology : JAT},
  year={2015},
  volume={35 2},
  pages={133-41}
}
Dimethylarsinic acid (DMA(V) ), the major urinary metabolite of inorganic arsenic, is a urinary bladder carcinogen and bladder tumor promoter in adult rats. Increased urothelial cellular proliferation has been considered as an earlier phenotype in DMA(V) -induced bladder carcinogenesis. The present study examined the ultrastructural changes of bladder epithelial cells and expressions of proliferation factors, as well as the secretion of inflammatory cytokines in rats exposed to DMA(V) for 10… CONTINUE READING