Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice.

@article{Arnold2006DimethylarsinicAR,
  title={Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice.},
  author={Lora L. Arnold and Michal Eldan and Abraham Nyska and Marcia van Gemert and Samuel M Cohen},
  journal={Toxicology},
  year={2006},
  volume={223 1-2},
  pages={
          82-100
        }
}
Dimethylarsinic acid (DMA(V), cacodylic acid), a foliar herbicide, was administered in the diet to B6C3F1 mice (at dose levels of 0, 8, 40, 200, and 500 ppm) and to F344 rats (at dose levels of 0, 2, 10, 40, and 100 ppm) for 2 years, according to US EPA guidelines. In mice, there were no treatment-related tumors observed at any site. Treatment-related progressive glomerulonephropathy and nephrocalcinosis were observed in the kidneys in both sexes. The incidence of vacuolation of the epithelium… CONTINUE READING
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