Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells.

@article{Hasegawa2006DimethylarginineD2,
  title={Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells.},
  author={Kazuhiro Hasegawa and Shu Wakino and Toru Tanaka and Masumi Kimoto and Satoru Tatematsu and Takeshi Kanda and Kyoko Yoshioka and Koichiro Homma and Naoki Sugano and Masahiko Kurabayashi and Takao Saruta and Koichi Hayashi},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 7},
  pages={1488-94}
}
OBJECTIVE Dimethylarginie dimethylaminohydrolase (DDAH) is a degrading enzyme for asymmetrical dimethylarginine, an endogenous NO synthase inhibitor. The molecular mechanism for DDAH-induced vascular endothelial growth factor (VEGF) expression was examined. METHODS AND RESULTS Although the transfection of expression vectors for 2 isoforms of DDAH, DDAH1, or DDAH2 increased DDAH activity in bovine aortic endothelial cells and human umbilical vein endothelial cells, expression and secretion of… CONTINUE READING