Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity

  title={Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity},
  author={Richard D'Mello and Claire A. Sand and Sophie Pezet and James Leiper and Egle Gaurilcikaite and Stephen B. McMahon and Anthony Henry Dickenson and Manasi Nandi},
  pages={2052 - 2060}
Abstract Activation of neuronal nitric oxide synthase, and consequent production of nitric oxide (NO), contributes to spinal hyperexcitability and enhanced pain sensation. All NOS isoforms are inhibited endogenously by asymmetric dimethylarginine, which itself is metabolised by dimethylarginine dimethylaminohydrolase (DDAH). Inhibition of DDAH can indirectly attenuate NO production by elevating asymmetric dimethylarginine concentrations. Here, we show that the DDAH-1 isoform is constitutively… 
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