Dimethyl sulfoxide decreases interleukin-8-mediated neutrophil recruitment in the airways.

@article{Massion1996DimethylSD,
  title={Dimethyl sulfoxide decreases interleukin-8-mediated neutrophil recruitment in the airways.},
  author={Pierre P. Massion and Annette Linden and Hiroyasu Inoue and Marianne Mathy and Kate Grattan and J. Ramachandran},
  journal={The American journal of physiology},
  year={1996},
  volume={271 5 Pt 1},
  pages={
          L838-43
        }
}
In this study, we investigated the role of dimethyl sulfoxide (DMSO) in inhibiting interleukin-8 (IL-8)-mediated neutrophil recruitment induced by Pseudomonas aeruginosa (PA) bacterial supernatant. First, we tested whether DMSO could inhibit IL-8 production induced by PA in human bronchial epithelial (16-HBE) cells in vitro. In these cells, exposure to PA or H2O2 induced IL-8 production dose dependently, an effect that was inhibited by 1% DMSO at both the protein and RNA level. Second, we… CONTINUE READING
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